About the Authors

Chih-Ya Wang

Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

An-Chi Tsai

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

Chieh-Yu Peng

Affiliations Natural Medicinal Products Research Center, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

Ya-Ling Chang

Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

Kuo-Hsiung Lee

Affiliations Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

Che-Ming Teng

Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

apan0826@nhri.org.tw (SP); cmteng@ntu.edu.tw(CT)

Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

Shiow-Lin Pan

Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

apan0826@nhri.org.tw (SP); cmteng@ntu.edu.tw(CT)

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CW AT KL CT SP. Performed the experiments: CW AT CP YC SP. Analyzed the data: CW AT CT SP. Contributed reagents/materials/analysis tools: CW AT CP YC KL CT SP. Wrote the paper: CW CT SP.