About the Authors
- Heng Wei
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Contributed equally to this work with: Heng Wei, Chunxiu Hu, Mei Wang
Affiliations Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands, Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands
- Chunxiu Hu
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Contributed equally to this work with: Heng Wei, Chunxiu Hu, Mei Wang
Affiliations Division of Analytical Bioscience, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
- Mei Wang
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Contributed equally to this work with: Heng Wei, Chunxiu Hu, Mei Wang
Affiliations Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Zeist, The Netherlands
- Anita M. van den Hoek
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Affiliation Metabolic Health Research, TNO, Leiden, The Netherlands
- Theo H. Reijmers
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Affiliations Division of Analytical Bioscience, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands
- Suzan Wopereis
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Affiliation Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Jildau Bouwman
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Affiliations Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands
- Raymond Ramaker
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Affiliation Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Henrie A. A. J. Korthout
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Affiliation Fytagoras B.V, Leiden, The Netherlands
- Marco Vennik
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Affiliation Fytagoras B.V, Leiden, The Netherlands
- Thomas Hankemeier
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Affiliations Division of Analytical Bioscience, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands
- Louis M. Havekes
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Affiliations Metabolic Health Research, TNO, Leiden, The Netherlands, Department of Endocrinology and Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
- Renger F. Witkamp
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Affiliation Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
- Elwin R. Verheij
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Affiliation Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Guowang Xu
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* E-mail: jan.vandergreef@tno.nl (JVDG); xugw@dicp.ac.cn (GX)
Affiliations Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
- Jan van der Greef
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* E-mail: jan.vandergreef@tno.nl (JVDG); xugw@dicp.ac.cn (GX)
Affiliations Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands, Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, Division of Analytical Bioscience, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, SU BioMedicine, Zeist, The Netherlands
Competing Interests
The authors have read the journal's policy and have the following conflicts: Authors employed by SU Biomedicine (Mei Wang and Jan van der Greef) have a potential conflict of interest as their company may benefit from knowledge of the product investigated, which is generated on the basis of the published data. The authors will, however, not receive additional salary, additional personal income, or any form of financial support based on this study or the direct outcome. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MW AMvdH LMH JvdG. Performed the experiments: HW CH AMvdH RR HAAJK MV. Analyzed the data: HW CH AMvdH THR HAAJK MV ERV. Contributed reagents/materials/analysis tools: AMvdH RR HAAJK MV ERV. Wrote the paper: HW CH MW RFW AMvdH SW JB. Wrote the first draft of the manuscript: HW CH MW RFW. Contributed to the writing and revision of the manuscript: HW CH MW RFW AMvdH THR SW JB RR HAAJK MV TH LMH ERV GX JvdG.