About the Authors

Jiunn-Min Shieh

Affiliation Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan

Tzu-Tang Wei

Affiliation Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

Yen-An Tang

Affiliation Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan

Sin-Ming Huang

Affiliation Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

Wei-Ling Wen

Affiliation Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

Mei-Yu Chen

Affiliation Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

Hung-Chi Cheng

Affiliations Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan, Institute of Biochemistry, National Cheng Kung University, Tainan, Taiwan

Santosh B. Salunke

Affiliation Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

Ching-Shih Chen

Affiliation Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Pinpin Lin

Affiliation Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan

Chien-Tien Chen

ycw5798@mail.ncku.edu.tw (Y-CW); ctchen@mx.nthu.edu.tw (C-TC)

Affiliation Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

Yi-Ching Wang

ycw5798@mail.ncku.edu.tw (Y-CW); ctchen@mx.nthu.edu.tw (C-TC)

Affiliations Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan, Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Y-CW C-TC. Performed the experiments: J-MS T-TW Y-AT S-MH W-LW M-YC H-CC SBS PL. Analyzed the data: J-MS T-TW Y-AT S-MH W-LW. Contributed reagents/materials/analysis tools: H-CC SBS C-SC C-TC. Wrote the paper: Y-CW J-MS T-TW C-TC.