The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi

Arunkumar Krishnan; Markus Sällman Almén; Robert Fredriksson; Helgi B. Schiöth

doi:10.1371/journal.pone.0029817

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Open Access

Peer-reviewed

Research Article

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi

Arunkumar Krishnan ,

Contributed equally to this work with: Arunkumar Krishnan, Markus Sällman Almén

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
⨯
Markus Sällman Almén ,

Contributed equally to this work with: Arunkumar Krishnan, Markus Sällman Almén

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
⨯
Robert Fredriksson,

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
⨯
Helgi B. Schiöth

* E-mail: helgi.schioth@neuro.uu.se

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
⨯

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi

Arunkumar Krishnan,
Markus Sällman Almén,
Robert Fredriksson,
Helgi B. Schiöth

Published: January 4, 2012
https://doi.org/10.1371/journal.pone.0029817

About the Authors

Arunkumar Krishnan

Contributed equally to this work with: Arunkumar Krishnan, Markus Sällman Almén

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden

Markus Sällman Almén

Contributed equally to this work with: Arunkumar Krishnan, Markus Sällman Almén

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden

Robert Fredriksson

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden

Helgi B. Schiöth

* E-mail: helgi.schioth@neuro.uu.se

Affiliation Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK MSA. Performed the experiments: AK MSA. Analyzed the data: AK MSA. Contributed reagents/materials/analysis tools: RF HBS. Wrote the paper: AK MSA RF HBS.

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Fungi
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Protein domains
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G protein coupled receptors
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Glutamate
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Eukaryota
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Phylogenetic analysis
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Fungal genomics
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Hidden Markov models
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