About the Authors

Kazue Masuko

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Shogo Okazaki

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Mayumi Satoh

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Goh Tanaka

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Tatsuya Ikeda

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Ryota Torii

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Eri Ueda

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Takashi Nakano

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Masaaki Danbayashi

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Tomoyo Tsuruoka

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Yoshiya Ohno

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Hideki Yagi

Affiliation Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan

Noritsugu Yabe

Affiliation Kohjin Bio Co., Ltd., Saitama, Japan

Hideaki Yoshida

Affiliation Kyowa Hakko Kirin Co., Ltd., Chiyoda-ku, Tokyo, Japan

Tomoyuki Tahara

Affiliation Kyowa Hakko Kirin Co., Ltd., Chiyoda-ku, Tokyo, Japan

Shiro Kataoka

Affiliation Kyowa Hakko Kirin Co., Ltd., Chiyoda-ku, Tokyo, Japan

Taichi Oshino

Affiliation Link Genomics, Inc., Chuo-ku, Tokyo, Japan

Takayuki Shindo

Affiliation Link Genomics, Inc., Chuo-ku, Tokyo, Japan

Shin-ichiro Niwa

Affiliation Link Genomics, Inc., Chuo-ku, Tokyo, Japan

Takatsugu Ishimoto

Affiliation Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Honjo, Kumamoto, Japan

Hideo Baba

Affiliation Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Honjo, Kumamoto, Japan

Yoshiyuki Hashimoto

† Deceased.

Affiliation Tohoku University, Sendai, Japan

Hideyuki Saya

Affiliation Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

Takashi Masuko

masuko@phar.kindai.ac.jp

Affiliations Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan, Pharmaceutical Research and Technology Institute, Kinki University, Higashiosaka-shi, Osaka, Japan

Competing Interests

In this investigation, corresponding author (TM) collaborated with Kohjin Bio Co., Ltd in the study of ADCC, with Kyowa Hakko Kirin Co., Ltd in the use of KM mice, and with Link Genomics, Inc. in the study of immunohistochemistry. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YH HS TM. Performed the experiments: KM SO MS GT T.Ikeda RT EU TN MD T.Tsuruoka YO H.Yagi NY H.Yoshida TO T.Ishimoto TM. Analyzed the data: KM SO H.Yagi NY H.Yoshida TS S-iN TM. Contributed reagents/materials/analysis tools: KM H.Yoshida T.Tahara SK TS S-iN HB HS TM. Wrote the paper: TM.