Distinct Roles for Aryl Hydrocarbon Receptor Nuclear Translocator and Ah Receptor in Estrogen-Mediated Signaling in Human Cancer Cell Lines

Mark P. Labrecque; Mandeep K. Takhar; Brett D. Hollingshead; Gratien G. Prefontaine; Gary H. Perdew; Timothy V. Beischlag

doi:10.1371/journal.pone.0029545

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Open Access

Peer-reviewed

Research Article

Distinct Roles for Aryl Hydrocarbon Receptor Nuclear Translocator and Ah Receptor in Estrogen-Mediated Signaling in Human Cancer Cell Lines

Mark P. Labrecque,

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
⨯
Mandeep K. Takhar,

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
⨯
Brett D. Hollingshead,

Affiliation Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Pennsylvania, United States of America
⨯
Gratien G. Prefontaine,

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
⨯
Gary H. Perdew,

Affiliation Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Pennsylvania, United States of America
⨯
Timothy V. Beischlag

* E-mail: tvb@sfu.ca

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
⨯

Distinct Roles for Aryl Hydrocarbon Receptor Nuclear Translocator and Ah Receptor in Estrogen-Mediated Signaling in Human Cancer Cell Lines

Mark P. Labrecque,
Mandeep K. Takhar,
Brett D. Hollingshead,
Gratien G. Prefontaine,
Gary H. Perdew,
Timothy V. Beischlag

Published: January 3, 2012
https://doi.org/10.1371/journal.pone.0029545

About the Authors

Mark P. Labrecque

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

Mandeep K. Takhar

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

Brett D. Hollingshead

Affiliation Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Pennsylvania, United States of America

Gratien G. Prefontaine

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

Gary H. Perdew

Affiliation Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Pennsylvania, United States of America

Timothy V. Beischlag

* E-mail: tvb@sfu.ca

Affiliation The Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TVB GHP GGP. Performed the experiments: MPL MKT BDH. Analyzed the data: TVB MPL GGP. Contributed reagents/materials/analysis tools: TVB GHP GGP. Wrote the paper: MPL TVB GGP GHP BDH.

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Small interfering RNA
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Transcription factors
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Transfection
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DNA transcription
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Estrogens
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Gene expression
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Breast cancer
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Polymerase chain reaction
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