About the Authors

Yin Zhang

Affiliation Department of Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Hao Hong

Affiliation Department of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Jonathan W. Engle

Affiliation Department of Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Jero Bean

Affiliation Department of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Yunan Yang

Affiliation Department of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Bryan R. Leigh

Affiliation TRACON Pharmaceuticals, Inc., San Diego, California, United States of America

Todd E. Barnhart

Affiliation Department of Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States of America

Weibo Cai

wcai@uwhealth.org

Affiliations Department of Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States of America, Department of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: BRL is an employee of TRACON Pharmaceuticals, Inc. Patent Number: US 5,928,641 Date Patent Issued: July 27, 1999 Title of Patent: Anti-Endoglin Monoclonal Antibodies and Their Use in Antiangiogenic Therapy Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY Patent Number: US 6,190,660 B1 Date Patent Issued: February 20, 2001 Title of Patent: Anti-Endoglin Monoclonal Antibodies and Their Use in Antiangiogenic Therapy - Continuation in Part 1 Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY Patent Number: US 6,200,566 B1 Date Patent Issued: March 13, 2001 Title of Patent: Anti-Endoglin Monoclonal Antibodies and Their Use in Antiangiogenic Therapy - Continuation in Part 2 Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY Patent Number: European Patent No. 0,938,505 Date Patent Issued: March 6, 2002 Title of Patent: Anti-Endoglin Monoclonal Antibodies and Their Use in Antiangiogenic Therapy Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY Patent File Number: US 7,097,836 Date Patent Issued: August 29, 2006 Title of Patent: Method for Increasing Efficacy of Anti-Tumor Agents by Anti-Endoglin Antibody Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY Patent File Number: US 7,691,374 Date Patent Filed: April 6, 2010 Title of Patent: Method for Increasing Efficacy of Anti-Tumor Agents by Anti-Endoglin Antibody Assignee: Health Research Inc., Buffalo, NY Inventor: Ben K. Seon, Williamsville, NY The other authors declare that they have no conflict of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YZ HH WC. Performed the experiments: YZ HH JWE YY TEB. Analyzed the data: YZ HH JWE BRL WC. Contributed reagents/materials/analysis tools: BRL. Wrote the paper: YZ HH JB BRL WC.