About the Authors

Thomas Orfeo

Affiliation Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America

Matthew Gissel

Affiliation Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America

Saulius Butenas

Affiliation Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America

Anetta Undas

Affiliation Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland

Kathleen E. Brummel-Ziedins

Affiliation Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America

Kenneth G. Mann

kenneth.mann@uvm.edu

Affiliations Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America, Johnson & Johnson, Pharmaceutical Research and Development, Raritan, New Jersey, United States of America

Competing Interests

This work was supported in part by a grant from Johnson & Johnson. Kenneth G. Mann was a consultant for Johnson & Johnson during the time of this research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TO KGM KEB-Z SB. Performed the experiments: MG TO. Analyzed the data: MG TO. Contributed reagents/materials/analysis tools: AU. Wrote the paper: TO.