Using Amino Acid Correlation and Community Detection Algorithms to Identify Functional Determinants in Protein Families

Lucas Bleicher; Ney Lemke; Richard Charles Garratt

doi:10.1371/journal.pone.0027786

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Open Access

Peer-reviewed

Research Article

Using Amino Acid Correlation and Community Detection Algorithms to Identify Functional Determinants in Protein Families

Lucas Bleicher ,

* E-mail: lbleicher@icb.ufmg.br

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯
Ney Lemke,

Affiliation Departamento de Física e Biofísica, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil
⨯
Richard Charles Garratt

Affiliation Departamento de Física e Informática, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil
⨯

Using Amino Acid Correlation and Community Detection Algorithms to Identify Functional Determinants in Protein Families

Lucas Bleicher,
Ney Lemke,
Richard Charles Garratt

Published: December 20, 2011
https://doi.org/10.1371/journal.pone.0027786

About the Authors

Lucas Bleicher

* E-mail: lbleicher@icb.ufmg.br

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Ney Lemke

Affiliation Departamento de Física e Biofísica, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil

Richard Charles Garratt

Affiliation Departamento de Física e Informática, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LB RCG. Performed the experiments: LB. Analyzed the data: LB RCG NL. Contributed reagents/materials/analysis tools: LB. Wrote the paper: LB RCG.

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Peroxidases
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Sequence alignment
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Multiple alignment calculation
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Protein sequencing
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Superoxide dismutase
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Theoretical ecology
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Amino acid analysis
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Community structure
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