About the Authors

Tiago Beites

Contributed equally to this work with: Tiago Beites, Sílvia D. S. Pires

Affiliations IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Biologia, Faculdade de Ciências (FCUP), Universidade do Porto, Porto, Portugal

Sílvia D. S. Pires

Contributed equally to this work with: Tiago Beites, Sílvia D. S. Pires

Affiliations IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Catarina L. Santos

Affiliation IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

Hugo Osório

Affiliation IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

Pedro Moradas-Ferreira

Affiliations IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Marta V. Mendes

mvm@ibmc.up.pt

Affiliation IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

Competing Interests

A Portuguese provisional patent application based on this study was filed by IBMC, the institution to which TB, SP, CLS, PMF and MVM are affiliated; Reference Number 105848. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TB MVM. Performed the experiments: TB SDSP CLS HO MVM. Analyzed the data: TB CLS MVM. Wrote the paper: TB MVM. Participated in critical discussions and provided valuable suggestions: PM-F.