About the Authors

Brian Weiner

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

James Gomez

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Thomas C. Victor

Affiliation Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Sciences, National Research Foundation Centre of Excellence for Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa

Robert M. Warren

Affiliation Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Sciences, National Research Foundation Centre of Excellence for Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa

Alexander Sloutsky

Affiliation Massachusetts Supranational TB Reference Laboratory, Center for Health Policy and Research, University of Massachusetts Medical School, Shrewsbury, Massachusetts, United States of America

Bonnie B. Plikaytis

Affiliation Mycobacteriology Laboratory Branch, Division of TB Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

James E. Posey

Affiliation Mycobacteriology Laboratory Branch, Division of TB Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Paul D. van Helden

Affiliation Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Sciences, National Research Foundation Centre of Excellence for Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa

Nicolass C. Gey van Pittius

Affiliation Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Sciences, National Research Foundation Centre of Excellence for Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa

Michael Koehrsen

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Peter Sisk

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Christian Stolte

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Jared White

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Sebastien Gagneux

Affiliation Medical Research Council, National Institute for Medical Research, London, United Kingdom

Bruce Birren

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Deborah Hung

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Megan Murray

Contributed equally to this work with: Megan Murray, James Galagan

Affiliation Harvard School of Public Health, Boston, Massachusetts, United States of America

James Galagan

Contributed equally to this work with: Megan Murray, James Galagan

jgalag@bu.edu

Affiliations The Broad Institute, Cambridge, Massachusetts, United States of America, Department of Biomedical Engineering and Microbiology, Boston University, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: J. Galagan BB DH J. Gomez. Performed the experiments: DH J. Gomez. Analyzed the data: J. Galagan BW MK CS JW J. Gomez DH MM SG. Contributed reagents/materials/analysis tools: TCV RMW AS BBP JEP PDvH NCGvP DH MM PS SG. Wrote the paper: J. Galagan BW.