About the Authors

Brunilde Gril

grilbrun@mail.nih.gov

Affiliation Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Diane Palmieri

Affiliation Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Yong Qian

Affiliation Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Talha Anwar

Affiliation Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Lilia Ileva

Affiliation Laboratory Animal Science Program, Science Applications International Corporation-Frederick, National Cancer Institute- Frederick, Frederick, Maryland, United States of America

Marcelino Bernardo

Affiliations Laboratory Animal Science Program, Science Applications International Corporation-Frederick, National Cancer Institute- Frederick, Frederick, Maryland, United States of America, Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

Peter Choyke

Affiliation Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

David J. Liewehr

Affiliation Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America

Seth M. Steinberg

Affiliation Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America

Patricia S. Steeg

Affiliation Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Competing Interests

The authors declare a collaborative research agreement with GlaxoSmithKline. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BG DP PS. Performed the experiments: BG TA YQ. Analyzed the data: BG DP PS. Wrote the paper: BG DP PS. DCE-MRI studies were performed by: LI MB PC. Statistical analyses were performed by: SS DL. DCE-MRI studies were analyzed by: LI MB PC.