About the Authors

Giovanni Nardo

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Silvia Pozzi

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Mauro Pignataro

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Eliana Lauranzano

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Giorgia Spano

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy

Silvia Garbelli

Affiliations Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Salvatore Maugeri, Pavia, Italy, National Institute for Occupational Safety and Prevention (ISPESL), Research Center at the IRCCS Fondazione Salvatore Maugeri, Pavia, Italy

Stefania Mantovani

Affiliations Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Salvatore Maugeri, Pavia, Italy, National Institute for Occupational Safety and Prevention (ISPESL), Research Center at the IRCCS Fondazione Salvatore Maugeri, Pavia, Italy

Kalliopi Marinou

Affiliation IRCCS Fondazione Salvatore Maugeri, Milano, Italy

Laura Papetti

Affiliation IRCCS Fondazione Salvatore Maugeri, Milano, Italy

Marta Monteforte

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Valter Torri

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Luca Paris

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Gianfranco Bazzoni

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Christian Lunetta

Affiliation NEuroMuscular Omnicentre (NEMO), Niguarda Ca’ Granda Hospital, Milano, Italy

Massimo Corbo

Affiliation NEuroMuscular Omnicentre (NEMO), Niguarda Ca’ Granda Hospital, Milano, Italy

Gabriele Mora

Affiliation IRCCS Fondazione Salvatore Maugeri, Milano, Italy

Caterina Bendotti

Affiliation Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy

Valentina Bonetto

valentina.bonetto@marionegri.it

Affiliations Dulbecco Telethon Institute, Milano, Italy, Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy

Competing Interests

This work is part of a patent application yet to be published (US Provisional n.61/361,730: Multiprotein biomarkers of amyotrophic lateral sclerosis in peripheral blood mononuclear cells, diagnostic method and kits). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VB CB GM MC CL. Performed the experiments: GN SP MP EL GS SG SM. Analyzed the data: GN MM VT L. Paris GB CL MC GM CB VB. Wrote the paper: VB. Enrolled patients and collected blood samples: KM L. Papetti CL.