About the Authors

Nicole Speed

Contributed equally to this work with: Nicole Speed, Christine Saunders

Affiliation Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Christine Saunders

Contributed equally to this work with: Nicole Speed, Christine Saunders

Affiliation Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Adeola R. Davis

Affiliation Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

W. Anthony Owens

Affiliation Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Heinrich J. G. Matthies

Affiliation Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Sanaz Saadat

Affiliation Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

Jack P. Kennedy

Affiliation Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Roxanne A. Vaughan

Affiliation Department of Biochemistry and Molecular Biology, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America

Rachael L. Neve

Affiliation Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Craig W. Lindsley

Affiliation Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Scott J. Russo

Affiliation Department of Neuroscience, Mount Sinai Medical Center, New York, New York, United States of America

Lynette C. Daws

These authors also contributed equally to this work.

Affiliation Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Kevin D. Niswender1

These authors also contributed equally to this work.

Affiliations Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Aurelio Galli

aurelio.galli@vanderbilt.edu

These authors also contributed equally to this work.

Affiliations Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS CS AD WAO HJGM LCD KDN AG. Performed the experiments: NS CS AD WAO HJGM SS JPK. Analyzed the data: NS CS AD WAO HJGM. Contributed reagents/materials/analysis tools: JPK RAV RLN CWL SJR. Wrote the paper: NS CS LCD KDN AG.