About the Authors

Claudia Manzoni

Current address: Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Laura Colombo

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Paolo Bigini

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Valentina Diana

Current address: Istituto Auxologico Italiano, Milan, Italy

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Alfredo Cagnotto

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Massimo Messa

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Monica Lupi

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Valentina Bonetto

Affiliations Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy, Dulbecco Telethon Institute, Milan, Italy

Mauro Pignataro

Affiliations Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy, Dulbecco Telethon Institute, Milan, Italy

Cristina Airoldi

Affiliation Department. of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy

Erika Sironi

Affiliation Department. of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy

Alun Williams

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Mario Salmona

mario.salmona@marionegri.it

Affiliation Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy

Competing Interests

The authors have declared that no competing interests exist. The commercial funder "Banca IntesaSanPaolo" does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CM LC AW MS. Performed the experiments: CM LC PB ML VD MM MP CA ES. Analyzed the data: CM LC PB ML VB AW MS. Contributed reagents/materials/analysis tools: CM LC AC MM. Wrote the paper: CM MS.