Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice

Hannah M. Kaneb; Paul S. Sharp; Nazanin Rahmani-Kondori; Dominic J. Wells

doi:10.1371/journal.pone.0024189

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Open Access

Peer-reviewed

Research Article

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1^G93A Mouse Model of ALS and Is Harmful in Female Mice

Hannah M. Kaneb,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯
Paul S. Sharp,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, Sheffield University, Sheffield, United Kingdom
⨯
Nazanin Rahmani-Kondori,

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯
Dominic J. Wells

* E-mail: dwells@rvc.ac.uk

Affiliation Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
⨯

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1^G93A Mouse Model of ALS and Is Harmful in Female Mice

Hannah M. Kaneb,
Paul S. Sharp,
Nazanin Rahmani-Kondori,
Dominic J. Wells

Published: September 1, 2011
https://doi.org/10.1371/journal.pone.0024189

About the Authors

Hannah M. Kaneb

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom

Paul S. Sharp

Affiliations Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom, Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, Sheffield University, Sheffield, United Kingdom

Nazanin Rahmani-Kondori

Dominic J. Wells

* E-mail: dwells@rvc.ac.uk

Affiliation Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HMK DJW PSS. Performed the experiments: HMK NR-K. Analyzed the data: HMK. Contributed reagents/materials/analysis tools: DJW PSS. Wrote the paper: HMJ PSS NR-K DJW.

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