Probing the Role of Protein Surface Charge in the Activation of PrfA, the Central Regulator of Listeria monocytogenes Pathogenesis

Bobbi Xayarath; Karl W. Volz; Jennifer I. Smart; Nancy E. Freitag

doi:10.1371/journal.pone.0023502

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Open Access

Peer-reviewed

Research Article

Probing the Role of Protein Surface Charge in the Activation of PrfA, the Central Regulator of Listeria monocytogenes Pathogenesis

Bobbi Xayarath,

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Karl W. Volz,

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Jennifer I. Smart,

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Nancy E. Freitag

* E-mail: nfreitag@uic.edu

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

Probing the Role of Protein Surface Charge in the Activation of PrfA, the Central Regulator of Listeria monocytogenes Pathogenesis

Bobbi Xayarath,
Karl W. Volz,
Jennifer I. Smart,
Nancy E. Freitag

Published: August 12, 2011
https://doi.org/10.1371/journal.pone.0023502

About the Authors

Bobbi Xayarath

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America

Karl W. Volz

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America

Jennifer I. Smart

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America

Nancy E. Freitag

* E-mail: nfreitag@uic.edu

Affiliation Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BX KWV JIS NEF. Performed the experiments: BX JIS. Analyzed the data: BX KWV NEF. Wrote the paper: BX KWV NEF.

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Lysine
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DNA-binding proteins
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Substitution mutation
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Listeria monocytogenes
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Intracellular pathogens
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Gene expression
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Host cells
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