Phenothiourea Sensitizes Zebrafish Cranial Neural Crest and Extraocular Muscle Development to Changes in Retinoic Acid and IGF Signaling

Brenda L. Bohnsack; Donika Gallina; Alon Kahana

doi:10.1371/journal.pone.0022991

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Open Access

Peer-reviewed

Research Article

Phenothiourea Sensitizes Zebrafish Cranial Neural Crest and Extraocular Muscle Development to Changes in Retinoic Acid and IGF Signaling

Brenda L. Bohnsack,

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Donika Gallina,

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Alon Kahana

* E-mail: akahana@med.umich.edu

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯

Phenothiourea Sensitizes Zebrafish Cranial Neural Crest and Extraocular Muscle Development to Changes in Retinoic Acid and IGF Signaling

Brenda L. Bohnsack,
Donika Gallina,
Alon Kahana

Published: August 19, 2011
https://doi.org/10.1371/journal.pone.0022991

About the Authors

Brenda L. Bohnsack

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

Donika Gallina

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

Alon Kahana

* E-mail: akahana@med.umich.edu

Affiliation Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BLB AK. Performed the experiments: BLB DG. Analyzed the data: BLB DG AK. Contributed reagents/materials/analysis tools: BLB DG AK. Wrote the paper: BLB AK.

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Retinoic acid
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Jaw
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Neural crest
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Zebrafish
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Embryos
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Thyroid
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Developmental signaling
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Morpholino
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