About the Authors

Yun-Ju Chen

Contributed equally to this work with: Yun-Ju Chen, Wei-Chien Huang

Affiliation Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan

Wei-Chien Huang

Contributed equally to this work with: Yun-Ju Chen, Wei-Chien Huang

whuang@mail.cmu.edu.tw (W-CH); mhung@mdanderson.org (M-CH)

Affiliations Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan, Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan, Department of Biotechnology, Asia University, Taichung, Taiwan

Ya-Ling Wei

Affiliation Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan

Sheng-Chieh Hsu

Affiliation Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan

Ping Yuan

Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Heather Y. Lin

Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Ignacio I. Wistuba

Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

J. Jack Lee

Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Chia-Jui Yen

Affiliations Institute of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan, Internal Medicine, National Cheng-Kung University, Tainan, Taiwan

Wu-Chou Su

Affiliations Institute of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan, Internal Medicine, National Cheng-Kung University, Tainan, Taiwan

Kwang-Yu Chang

Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan

Wen-Chang Chang

Affiliation Department of Pharmacology, National Cheng-Kung University, Tainan, Taiwan

Tse-Chuan Chou

Affiliations Department of Chemical Engineering, National Cheng-Kung University, Tainan, Taiwan, Department of Chemical Engineering, Tatung University, Taipei, Taiwan

Chao-Kai Chou

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Chang-Hai Tsai

Affiliations Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, Department of Healthcare Administration, Asia University, Taichung, Taiwan

Mien-Chie Hung

whuang@mail.cmu.edu.tw (W-CH); mhung@mdanderson.org (M-CH)

Affiliations Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WCH YJC MCH. Performed the experiments: YJC WCH YLW SCH. Analyzed the data: PY HYL JJL. Contributed reagents/materials/analysis tools: IIW CJY WCS KYC WCC TCC CKC. Wrote the paper: WCH YJC MCH. Provided funding resources for the work: YJC WCH CHT MCH. Overall guidance and direction in all phases of experimental design, implementation, data acquisition and interpretation, and manuscript writing, editing and preparation: WCH MCH.