About the Authors

Fadhel S. Shaheen

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Pawel Znojek

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Ann Fisher

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Martin Webster

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Ruth Plummer

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Luke Gaughan

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Graeme C. M. Smith

Affiliation KuDOS Pharmaceuticals Ltd, Cambridge, United Kingdom

Hing Y. Leung

Affiliation The Beatson Institute for Cancer Research, Glasgow, United Kingdom

Nicola J. Curtin

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Craig N. Robson

C.N.Robson@ncl.ac.uk

Affiliation The Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Competing Interests

One of the authors, Graeme C.M. Smith, is employed by a commercial company, KuDOS Pharmaceuticals Ltd, Cambridge Science Park, Milton Road, Cambridge, UK. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FSH NJC CNR. Performed the experiments: FSH AF PZ MW. Analyzed the data: FSH PZ AF LG NJC CNR. Contributed reagents/materials/analysis tools: FSH GS NJC RP LG HL CNR. Wrote the paper: FSH NJC RP HL LG CNR.