About the Authors

Pascal Bonaventure

Pbonave1@its.jnj.com

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Leah Aluisio

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

James Shoblock

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Jamin D. Boggs

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Ian C. Fraser

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Brian Lord

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Timothy W. Lovenberg

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Ruggero Galici

Current address: Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Affiliation Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: This work was funded by Johnson & Johnson Pharmaceutical Research and Development, L.L.C. All the authors were employees of Johnson & Johnson Pharmaceutical Research and Development, L.L.C. when the work was done. The funders had a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to all the PLoS ONE policies.

Author Contributions

Conceived and designed the experiments: PB RG TL LA. Performed the experiments: LA JB BL IF. Analyzed the data: JS LA RG PB. Contributed reagents/materials/analysis tools: JS. Wrote the paper: PB RG JS.