αA-Crystallin Peptide 66SDRDKFVIFLDVKHF80 Accumulating in Aging Lens Impairs the Function of α-Crystallin and Induces Lens Protein Aggregation

Puttur Santhoshkumar; Murugesan Raju; K. Krishna Sharma

doi:10.1371/journal.pone.0019291

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Peer-reviewed

Research Article

αA-Crystallin Peptide ⁶⁶SDRDKFVIFLDVKHF⁸⁰ Accumulating in Aging Lens Impairs the Function of α-Crystallin and Induces Lens Protein Aggregation

Puttur Santhoshkumar,

Affiliation Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America
⨯
Murugesan Raju,

Affiliation Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America
⨯
K. Krishna Sharma

* E-mail: sharmak@health.missouri.edu

Affiliations Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America, Department of Biochemistry, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America
⨯

αA-Crystallin Peptide ⁶⁶SDRDKFVIFLDVKHF⁸⁰ Accumulating in Aging Lens Impairs the Function of α-Crystallin and Induces Lens Protein Aggregation

Puttur Santhoshkumar,
Murugesan Raju,
K. Krishna Sharma

Published: April 28, 2011
https://doi.org/10.1371/journal.pone.0019291

About the Authors

Puttur Santhoshkumar

Affiliation Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America

Murugesan Raju

Affiliation Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America

K. Krishna Sharma

* E-mail: sharmak@health.missouri.edu

Affiliations Department of Ophthalmology, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America, Department of Biochemistry, University of Missouri–Columbia School of Medicine, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKS PS MR. Performed the experiments: PS MR. Analyzed the data: KKS PS MR. Contributed reagents/materials/analysis tools: KKS. Wrote the paper: KKS PS MR.

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Cataracts
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Optical lenses
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Eye lens
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Chemical precipitation
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Protein aggregation
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Protein extraction
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Centrifugation
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Light scattering
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