About the Authors

Danielle Frost

Affiliations Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America, Arizona Alzheimer's Research Consortium, Phoenix, Arizona, United States of America

Bessie Meechoovet

Affiliations Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America, Arizona Alzheimer's Research Consortium, Phoenix, Arizona, United States of America

Tong Wang

Affiliation Translational Drug Development, Translational Genomics Research Institute, Scottsdale, Arizona, United States of America

Stephen Gately

Affiliation Translational Drug Development, Translational Genomics Research Institute, Scottsdale, Arizona, United States of America

Marco Giorgetti

Affiliation MediProPharma, Inc., Salt Lake City, Utah, United States of America

Irina Shcherbakova

Affiliation MediProPharma, Inc., Salt Lake City, Utah, United States of America

Travis Dunckley

tdunckley@tgen.org

Affiliations Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America, Arizona Alzheimer's Research Consortium, Phoenix, Arizona, United States of America

Competing Interests

Studies involving the compounds MPP-021 and MPP-313 were funded by MediProPharma, Inc. For these studies, MediProPharma provided TGen with adequate amounts of each compound, their data determining the IC50's for these compounds against DYRK1A, and paid TGen's reagent costs to analyze these compounds. The specific experiments performed were conceived, carried out, and analyzed by TGen with no subsequent input from MediProPharma. Proprietary MPP compounds are available from MediProPharma through completion of a material transfer agreement. MediProPharma's role in this study does not alter our adherence to PLoS One's policy for sharing data and materials.

Author Contributions

Conceived and designed the experiments: TD. Performed the experiments: DF BM TW. Analyzed the data: DF BM TD. Contributed reagents/materials/analysis tools: MG IS SG TW. Wrote the paper: TD DF BM.