About the Authors

Alexandra Rogue

Affiliations UMR INSERM U991, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes, France, Université de Rennes 1, Rennes, France, Biologie Servier, Gidy, France

Carine Lambert

Affiliations UMR INSERM U991, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes, France, Université de Rennes 1, Rennes, France

Rozenn Jossé

Affiliations UMR INSERM U991, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes, France, Université de Rennes 1, Rennes, France

Sebastien Antherieu

Affiliations UMR INSERM U991, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes, France, Université de Rennes 1, Rennes, France

Catherine Spire

andre.guillouzo@univ-rennes1.fr (AG); catherine.spire@fr.netgrs.com (CS)

Affiliation Biologie Servier, Gidy, France

Nancy Claude

Affiliation Institut de Recherches Servier, Courbevoie, France

André Guillouzo

andre.guillouzo@univ-rennes1.fr (AG); catherine.spire@fr.netgrs.com (CS)

Affiliations UMR INSERM U991, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes, France, Université de Rennes 1, Rennes, France

Competing Interests

CS and NC are employed by Biologie Servier (French pharmaceutical firm). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AR CL RJ SA CS NC AG. Performed the experiments: AR CL RJ SA. Analyzed the data: AR CL RJ SA AG. Contributed reagents/materials/analysis tools: AR CL RJ SA AG. Wrote the paper: AR AG.