A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice

Linghua Qiu; Jaime A. Rivera-Pérez; Zuoshang Xu

doi:10.1371/journal.pone.0018778

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Peer-reviewed

Research Article

A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice

Linghua Qiu,

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Jaime A. Rivera-Pérez,

Affiliation Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Zuoshang Xu

* E-mail: Zuoshang.xu@umassmed.edu

Affiliations Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice

Linghua Qiu,
Jaime A. Rivera-Pérez,
Zuoshang Xu

Published: May 10, 2011
https://doi.org/10.1371/journal.pone.0018778

About the Authors

Linghua Qiu

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Jaime A. Rivera-Pérez

Affiliation Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Zuoshang Xu

* E-mail: Zuoshang.xu@umassmed.edu

Affiliations Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LQ ZX. Performed the experiments: LQ. Analyzed the data: LQ ZX. Contributed reagents/materials/analysis tools: JAR. Wrote the paper: ZX LQ JAR.

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Genetically modified animals
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MicroRNAs
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Polymerase chain reaction
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Cell death
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Green fluorescent protein
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