Activation of cGMP-Dependent Protein Kinase Stimulates Cardiac ATP-Sensitive Potassium Channels via a ROS/Calmodulin/CaMKII Signaling Cascade

Yongping Chai; Dai-Min Zhang; Yu-Fung Lin

doi:10.1371/journal.pone.0018191

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Open Access

Peer-reviewed

Research Article

Activation of cGMP-Dependent Protein Kinase Stimulates Cardiac ATP-Sensitive Potassium Channels via a ROS/Calmodulin/CaMKII Signaling Cascade

Yongping Chai,

Affiliation Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America
⨯
Dai-Min Zhang,

Affiliation Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America
⨯
Yu-Fung Lin

* E-mail: yu-fung.lin@ucdmc.ucdavis.edu

Affiliations Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America, Department of Anesthesiology, University of California Davis, Davis, California, United States of America
⨯

Activation of cGMP-Dependent Protein Kinase Stimulates Cardiac ATP-Sensitive Potassium Channels via a ROS/Calmodulin/CaMKII Signaling Cascade

Yongping Chai,
Dai-Min Zhang,
Yu-Fung Lin

Published: March 29, 2011
https://doi.org/10.1371/journal.pone.0018191

About the Authors

Yongping Chai

Affiliation Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America

Dai-Min Zhang

Affiliation Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America

Yu-Fung Lin

* E-mail: yu-fung.lin@ucdmc.ucdavis.edu

Affiliations Departments of Physiology and Membrane Biology, University of California Davis, Davis, California, United States of America, Department of Anesthesiology, University of California Davis, Davis, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YFL. Performed the experiments: YC DZ. Analyzed the data: YC DZ YFL. Wrote the manuscript: YFL.

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Single channel recording
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Cardiomyocytes
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Redox signaling
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Phosphorylation
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Transfection
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Immune receptor signaling
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Intracellular membranes
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