About the Authors

Masahiro Mishina

mishina@nms.ac.jp

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan, Department of Neurology, Nippon Medical School Chiba Hokusoh Hospital, Inzai-shi, Chiba, Japan

Kiichi Ishiwata

Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Mika Naganawa

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, Department of Diagnostic Radiology, PET Center, Yale University, New Haven, Connecticut, United States of America

Yuichi Kimura

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

Shin Kitamura

Affiliations The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan, Department of Internal Medicine, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Kanagawa, Japan

Masahiko Suzuki

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, Department of Neurology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan

Masaya Hashimoto

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, Department of Neurology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan

Kenji Ishibashi

Affiliations Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan, Department of Neurology and Neurological Science Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Keiichi Oda

Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Muneyuki Sakata

Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Makoto Hamamoto

Affiliations The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan, Department of Neurology, Nippon Medical School Chiba Hokusoh Hospital, Inzai-shi, Chiba, Japan

Shiro Kobayashi

Affiliation Department of Neurosurgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai-shi, Chiba, Japan

Yasuo Katayama

Affiliation The Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan

Kenji Ishii

Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM K. Ishiwata K. Ishii. Performed the experiments: MM K. Ishiwata M. Hashimoto K. Ishibashi KO K. Ishii. Analyzed the data: MM MN Y. Kimura M. Sakata. Contributed reagents/materials/analysis tools: MM K. Ishiwata MN S. Kitamura M. Suzuki M. Hashimoto K. Ishibashi KO M. Hamamoto S. Kobayashi Y. Katayama K. Ishii. Wrote the paper: MM K. Ishiwata MN Y. Kimura S. Kobayashi. Selection of subjects: S. Kitamura M. Suzuki M. Hashimoto K. Ishibashi K. Ishii.