About the Authors

Hitomi Ohta

htmohta@hayashibara.co.jp

Affiliation Research Center, Biomedical Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan

Shigeyuki Arai

Affiliation Research Center, Biomedical Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan

Kenji Akita

Affiliation Research Center, Biomedical Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan

Tsunetaka Ohta

Affiliation Research Center, Biomedical Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan

Shigeharu Fukuda

Affiliation Research Center, Biomedical Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan

Competing Interests

The authors are employees of, and funded by Hayashibara Biochemical Laboratories Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HO TO SF. Performed the experiments: HO SA. Analyzed the data: HO SA. Contributed reagents/materials/analysis tools: HO. Wrote the manuscript: HO SA KA SF.