Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers

Phillip M. Pifer; Elizabeth A. Yates; Justin Legleiter

doi:10.1371/journal.pone.0016248

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Open Access

Peer-reviewed

Research Article

Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers

Phillip M. Pifer,

Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Elizabeth A. Yates,

Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Justin Legleiter

* E-mail: justin.legleiter@mail.wvu.edu

Affiliations The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America, WVnano Initiative, West Virginia University, Morgantown, West Virginia, United States of America, The Center for Neurosciences, West Virginia University, Morgantown, West Virginia, United States of America
⨯

Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers

Phillip M. Pifer,
Elizabeth A. Yates,
Justin Legleiter

Published: January 18, 2011
https://doi.org/10.1371/journal.pone.0016248

About the Authors

Phillip M. Pifer

Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

Elizabeth A. Yates

Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

Justin Legleiter

* E-mail: justin.legleiter@mail.wvu.edu

Affiliations The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America, WVnano Initiative, West Virginia University, Morgantown, West Virginia, United States of America, The Center for Neurosciences, West Virginia University, Morgantown, West Virginia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL. Performed the experiments: PMP EAY JL. Analyzed the data: PMP JL. Contributed reagents/materials/analysis tools: JL. Wrote the paper: PMP EAY JL.

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Oligomers
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Lipid bilayer
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Lipids
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Membrane potential
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Lipid aggregates
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