Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPARγ Independent Manner

Linah Al-Alem; R. Chase Southard; Michael W. Kilgore; Thomas E. Curry

doi:10.1371/journal.pone.0016179

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Peer-reviewed

Research Article

Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPARγ Independent Manner

Linah Al-Alem,

Affiliations Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
R. Chase Southard,

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Michael W. Kilgore,

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Thomas E. Curry

* E-mail: tecurry@uky.edu

Affiliation Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯

Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPARγ Independent Manner

Linah Al-Alem,
R. Chase Southard,
Michael W. Kilgore,
Thomas E. Curry

Published: January 21, 2011
https://doi.org/10.1371/journal.pone.0016179

About the Authors

Linah Al-Alem

Affiliations Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

R. Chase Southard

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Michael W. Kilgore

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Thomas E. Curry

* E-mail: tecurry@uky.edu

Affiliation Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LFA RCS MWK TEC. Performed the experiments: LFA RCS MWK TEC. Analyzed the data: LFA RCS MWK TEC. Contributed reagents/materials/analysis tools: LFA RCS MWK TEC. Wrote the paper: LFA RCS MWK TEC.

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Ovarian cancer
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Cancer treatment
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Transfection
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Cell proliferation
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Cell cycle and cell division
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Apoptosis
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Protein expression
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Breast cancer
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