Rapamycin Blocks Production of KSHV/HHV8: Insights into the Anti-Tumor Activity of an Immunosuppressant Drug

Lisa A. Nichols; Laura A. Adang; Dean H. Kedes

doi:10.1371/journal.pone.0014535

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Peer-reviewed

Research Article

Rapamycin Blocks Production of KSHV/HHV8: Insights into the Anti-Tumor Activity of an Immunosuppressant Drug

Lisa A. Nichols,

Affiliations Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Laura A. Adang,

Affiliations Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Dean H. Kedes

* E-mail: kedes@virginia.edu

Affiliations Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯

Rapamycin Blocks Production of KSHV/HHV8: Insights into the Anti-Tumor Activity of an Immunosuppressant Drug

Lisa A. Nichols,
Laura A. Adang,
Dean H. Kedes

Published: January 14, 2011
https://doi.org/10.1371/journal.pone.0014535

About the Authors

Lisa A. Nichols

Affiliations Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America

Laura A. Adang

Dean H. Kedes

* E-mail: kedes@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LAN LAA DHK. Performed the experiments: LAN LAA. Analyzed the data: LAN LAA DHK. Wrote the paper: LAN LAA DHK.

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Cell staining
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Kaposi's sarcoma-associated herpesvirus
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Viral replication
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Flow cytometry
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Cancers and neoplasms
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Virions
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HeLa cells
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Immunoblotting
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