About the Authors

Taisuke Kato

Affiliation Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan

Atsushi Kasai

Affiliation Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan

Makoto Mizuno

Affiliations Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan, Center for Transdisciplinary Research, Niigata University, Niigata, Japan

Liang Fengyi

Affiliation Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Norihito Shintani

Affiliation Department of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan

Sadaaki Maeda

Affiliation Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan

Minesuke Yokoyama

Affiliation Center for Bioresource-Based Researches, Brain Research Institute, Niigata University, Niigata, Japan

Miwako Ozaki

Affiliations Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokyo, Japan, Neuroscience and Neuroengineering Group, Waseda Bioscience Institute of Singapore (WABIOS), Helios, Singapore

Hiroyuki Nawa

hnawa@bri.niigata-u.ac.jp

Affiliations Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan, Center for Transdisciplinary Research, Niigata University, Niigata, Japan

Competing Interests

HN was a recipient of the research grants from Astrazeneca Pharmaceutical, Inc. This does not alter the authors' adherence to the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HN. Performed the experiments: TK AK MM LF MY. Analyzed the data: TK AK SM. Contributed reagents/materials/analysis tools: NS SM MY MO. Wrote the paper: TK HN.