Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

Elizabeth H. Humphreys; Kevin T. Williams; David H. Adams; Simon C. Afford

doi:10.1371/journal.pone.0014037

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Open Access

Peer-reviewed

Research Article

Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

Elizabeth H. Humphreys,

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
⨯
Kevin T. Williams,

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
⨯
David H. Adams,

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
⨯
Simon C. Afford

* E-mail: s.c.afford@bham.ac.uk

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
⨯

Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

Elizabeth H. Humphreys,
Kevin T. Williams,
David H. Adams,
Simon C. Afford

Published: November 17, 2010
https://doi.org/10.1371/journal.pone.0014037

About the Authors

Elizabeth H. Humphreys

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom

Kevin T. Williams

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom

David H. Adams

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom

Simon C. Afford

* E-mail: s.c.afford@bham.ac.uk

Affiliation Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EH SA. Performed the experiments: EH. Analyzed the data: EH KTW SA. Contributed reagents/materials/analysis tools: KTW. Wrote the paper: EH SA. Offered expert advice on interpretation of data and manuscript preparation: DHA.

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Apoptosis
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Cholangiocarcinoma
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Neoplastic transformation
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Prostate cancer
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Hepatocytes
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Renal cancer
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Transcription factors
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CD coreceptors
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