About the Authors

Wen-I Wu

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Walter C. Voegtli

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Hillary L. Sturgis

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Faith P. Dizon

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Guy P. A. Vigers

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Barbara J. Brandhuber

bbrandhuber@arraybiopharma.com

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America

Competing Interests

Array BioPharma Inc. and Genentech, Inc. funded these studies. Wen-I Wu, Walter Voegtli, Hillary Sturgis, Guy Vigers, and Barbara Brandhuber are employees and stockholders of Array BioPharma Inc. Faith Dizon is a former employee of Array BioPharma Inc. Genentech, Inc. has products in development in this pathway. The authors agree to adhere to all the PLoS ONE policies on sharing data and materials, as detailed online in the PLoS ONE guide for authors. Array BioPharma Inc. and Genentech, Inc. approved this publication and adherence to the material and data sharing policies of the publishing journal.

Author Contributions

Conceived and designed the experiments: WIW BB. Performed the experiments: WIW WCV HLS FPD BB. Analyzed the data: WIW WCV GPAV BB. Wrote the paper: WIW WCV GPAV BB.