Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction

Zhong Yao; Seunghee Yoon; Eyal Kalie; Ziv Raviv; Rony Seger

doi:10.1371/journal.pone.0012627

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Open Access

Peer-reviewed

Research Article

Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction

Zhong Yao ,

Contributed equally to this work with: Zhong Yao, Seunghee Yoon

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Seunghee Yoon ,

Contributed equally to this work with: Zhong Yao, Seunghee Yoon

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Eyal Kalie,

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Ziv Raviv,

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Rony Seger

* E-mail: rony.seger@weizmann.ac.il

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯

Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction

Zhong Yao,
Seunghee Yoon,
Eyal Kalie,
Ziv Raviv,
Rony Seger

Published: September 7, 2010
https://doi.org/10.1371/journal.pone.0012627

About the Authors

Zhong Yao

Contributed equally to this work with: Zhong Yao, Seunghee Yoon

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Seunghee Yoon

Contributed equally to this work with: Zhong Yao, Seunghee Yoon

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Eyal Kalie

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Ziv Raviv

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Rony Seger

* E-mail: rony.seger@weizmann.ac.il

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZY SY EK ZR RS. Performed the experiments: ZY SY EK ZR. Analyzed the data: ZY SY EK ZR RS. Wrote the paper: ZY RS.

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Phosphorylation
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Calcium signaling cascade
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HeLa cells
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Immunoprecipitation
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Protein interactions
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MAPK signaling cascades
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Transfection
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Protein kinase signaling cascade
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