About the Authors

Yasutaka Mizoro

Contributed equally to this work with: Yasutaka Mizoro, Yoshiaki Yamaguchi

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Yoshiaki Yamaguchi

Contributed equally to this work with: Yasutaka Mizoro, Yoshiaki Yamaguchi

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Rena Kitazawa

Affiliation Division of Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan

Hiroyuki Yamada

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Masahiro Matsuo

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Jean-Michel Fustin

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Masao Doi

Affiliation Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan

Hitoshi Okamura

okamurah@pharm.kyoto-u.ac.jp

Affiliations Department of Systems Biology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan, Division of Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan

Competing Interests

This work was partially supported by Kanae Foundation for the Promotion of Medical Science. Kanae Foundation for the Promotion of Medical Science is financially supported by Sanofi-Aventis. However Sanofi-Aventis and Kanae Foundation for the Promotion of Medical Science do not have competing interests to the employment, consultancy, patents, products in development or marketed products, etc., related to the online manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YY HO. Performed the experiments: YM YY RK HY. Analyzed the data: YM YY MM JMF HO. Contributed reagents/materials/analysis tools: MD HO. Wrote the paper: YM YY HO.