About the Authors

Satya S. Varanasi

Contributed equally to this work with: Satya S. Varanasi, Ole K. Olstad

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Ole K. Olstad

Contributed equally to this work with: Satya S. Varanasi, Ole K. Olstad

Affiliation Department of Clinical Biochemistry, Oslo University Hospital, Ullevål, Norway

Daniel C. Swan

Affiliation Bioinformatics Support Unit, Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Paul Sanderson

Affiliation Department of Orthopaedic Surgery, Newcastle General Hospital, Newcastle Upon Tyne, United Kingdom

Vigdis T. Gautvik

Affiliations Department of Clinical Biochemistry, Oslo University Hospital, Ullevål, Norway, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

Sjur Reppe

Affiliations Department of Clinical Biochemistry, Oslo University Hospital, Ullevål, Norway, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

Roger M. Francis

Affiliation Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, United Kingdom

Kaare M. Gautvik

Affiliations Department of Clinical Biochemistry, Oslo University Hospital, Ullevål, Norway, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, Department of Clinical Chemistry, Lovisenberg Deacon Hospital, Oslo, Norway

Harish K. Datta

h.k.datta@ncl.ac.uk

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle Upon Tyne, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMG HKD. Performed the experiments: SSV OKO VTG. Analyzed the data: SSV OKO DCS HKD. Contributed reagents/materials/analysis tools: DCS SR RMF HKD. Wrote the paper: HKD. Performed subject clinical assessment: PS RMF KMG. Took biopsies: PS. Clinical assessment of the subjects: HKD.