About the Authors

Yannick D. Muller

Contributed equally to this work with: Yannick D. Muller, Gang Mai

leo.buhler@hcuge.ch

Affiliations Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland, Service of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerland

Gang Mai

Contributed equally to this work with: Yannick D. Muller, Gang Mai

Affiliations Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland, Hepato- Bilio-Pancreatic Department, West China Hospital, Si Chuan University, Chengdu, Si Chuan, People's Republic of China

Philippe Morel

Affiliation Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland

Véronique Serre-Beinier

Affiliation Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland

Carmen Gonelle-Gispert

Affiliation Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland

Gisella Puga Yung

Affiliation Service of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerland

Driss Ehirchiou

Affiliation Service of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerland

Jean-Christophe Wyss

Affiliation Transplantation Immunopathology Laboratory, Department of Medicine, University of Lausanne, Lausanne, Switzerland

Sinda Bigenzahn

Affiliation Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

Magali Irla

Affiliation University of Geneva Medical School, CMU, Geneva, Switzerland

Christoph Heusser

Affiliation Novartis Institutes for Biomedical Research, Basel, Switzerland

Déla Golshayan

Affiliation Transplantation Immunopathology Laboratory, Department of Medicine, University of Lausanne, Lausanne, Switzerland

Jörg D. Seebach

Affiliation Service of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerland

Thomas Wekerle

These authors also contributed equally to this work.

Affiliation Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

Leo H. Bühler

These authors also contributed equally to this work.

Affiliation Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland

Competing Interests

Novartis Pharma AG employed one of the authors of this study (Christoph Heusser, PhD) and provided several monoclonal antibodies (anti-CD25 mAb, anti-IL2). However there are no patents/products in development/marketed productions in relation to this research. Indeed, another company provides these antibodies. Thus this does not alter adherence to all the PLoS ONE policies on sharing data and materials, as detailed in the guide for authors.

Author Contributions

Conceived and designed the experiments: YDM GM SB TW LHB. Performed the experiments: YDM GM VSB CGG GLPY DE JCW SB MI. Analyzed the data: YDM GM DE MI DG JDS TW LHB. Contributed reagents/materials/analysis tools: PM DG JDS TW LHB. Wrote the paper: YDM GM GLPY DG TW LHB. Performed FACS analysis of blood and secondary lymphoid organs, conducted graft immunochemistry on para-aortic fin section and performed T regulatory suppression assays: YDM. Performed and followed rat islet transplantation of all groups and performed graft immunochemistry on cryostat section: GM. Provided several antibodies and helpful discussion: CH.