The Crystal Structure of PPIL1 Bound to Cyclosporine A Suggests a Binding Mode for a Linear Epitope of the SKIP Protein

Christian M. Stegmann; Reinhard Lührmann; Markus C. Wahl

doi:10.1371/journal.pone.0010013

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Research Article

The Crystal Structure of PPIL1 Bound to Cyclosporine A Suggests a Binding Mode for a Linear Epitope of the SKIP Protein

Christian M. Stegmann,

Affiliations Max-Planck-Institut für biophysikalische Chemie, Zelluläre Biochemie/Makromolekulare Röntgenkristallographie, Göttingen, Germany, Max-Planck-Institut für biophysikalische Chemie, AG Strukturbiochemie, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany
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Reinhard Lührmann,

Affiliation Max-Planck-Institut für biophysikalische Chemie, Zelluläre Biochemie/Makromolekulare Röntgenkristallographie, Göttingen, Germany
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Markus C. Wahl

* E-mail: mwahl@gwdg.de

Affiliations Max-Planck-Institut für biophysikalische Chemie, Zelluläre Biochemie/Makromolekulare Röntgenkristallographie, Göttingen, Germany, Max-Planck-Institut für biophysikalische Chemie, AG Strukturbiochemie, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany
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The Crystal Structure of PPIL1 Bound to Cyclosporine A Suggests a Binding Mode for a Linear Epitope of the SKIP Protein

Christian M. Stegmann,
Reinhard Lührmann,
Markus C. Wahl

Published: April 2, 2010
https://doi.org/10.1371/journal.pone.0010013

About the Authors

Christian M. Stegmann

Affiliations Max-Planck-Institut für biophysikalische Chemie, Zelluläre Biochemie/Makromolekulare Röntgenkristallographie, Göttingen, Germany, Max-Planck-Institut für biophysikalische Chemie, AG Strukturbiochemie, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany

Reinhard Lührmann

Affiliation Max-Planck-Institut für biophysikalische Chemie, Zelluläre Biochemie/Makromolekulare Röntgenkristallographie, Göttingen, Germany

Markus C. Wahl

* E-mail: mwahl@gwdg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMS RL MCW. Performed the experiments: CMS. Analyzed the data: CMS RL MCW. Contributed reagents/materials/analysis tools: CMS RL MCW. Wrote the paper: CMS RL MCW.

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Crystal structure
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Glutathione chromatography
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Spliceosomes
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Crystallization
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Crystals
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Protein interactions
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Electron density
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Molecular docking
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