About the Authors

Paul W. Hollenbach

Affiliation Celgene Corporation, San Francisco, California, United States of America

Aaron N. Nguyen

Affiliation Celgene Corporation, San Francisco, California, United States of America

Helen Brady

Affiliation Celgene Corporation, San Francisco, California, United States of America

Michelle Williams

Affiliation Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America

Yuhong Ning

Affiliation Celgene Corporation, San Francisco, California, United States of America

Normand Richard

Affiliation Celgene Corporation, San Francisco, California, United States of America

Leslie Krushel

Affiliation Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America

Sharon L. Aukerman

Affiliation Celgene Corporation, San Francisco, California, United States of America

Carla Heise

Affiliation Celgene Corporation, San Francisco, California, United States of America

Kyle J. MacBeth

kmacbeth@celgene.com

Affiliation Celgene Corporation, San Francisco, California, United States of America

Competing Interests

Vidaza is a marketed product with azacitidine as the active pharmaceutical ingredient. Dacogen is a marketed product with decitabine as the active pharmaceutical ingredient. The authors are able to adhere to the PLoS ONE policies on sharing data and materials. P.W.H., A.N.N., H.B., Y.N., N.R., S.L.A., C.H., and K.J.M. are employees of Celgene and as such own stock in the company. M.W. and L.K. received research support from Celgene.

Author Contributions

Conceived and designed the experiments: PWH ANN LK SLA CH KJM. Performed the experiments: PWH ANN HB MW NR. Analyzed the data: PWH ANN HB MW YN NR LK SLA CH KJM. Wrote the paper: PWH ANN KJM. Interpretation of data: PWH ANN HB MW YN NR LK SLA CH KJM. Critical review of manuscript content: PWH ANN HB MW YN NR LK SLA CH KJM.