The cAMP-Dependent Protein Kinase Inhibitor H-89 Attenuates the Bioluminescence Signal Produced by Renilla Luciferase

Katie J. Herbst; Michael D. Allen; Jin Zhang

doi:10.1371/journal.pone.0005642

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Open Access

Peer-reviewed

Research Article

The cAMP-Dependent Protein Kinase Inhibitor H-89 Attenuates the Bioluminescence Signal Produced by Renilla Luciferase

Katie J. Herbst,

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Michael D. Allen,

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jin Zhang

* E-mail: jzhang32@jhmi.edu

Affiliations Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The Solomon H. Snyder Department of Neuroscience and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

The cAMP-Dependent Protein Kinase Inhibitor H-89 Attenuates the Bioluminescence Signal Produced by Renilla Luciferase

Katie J. Herbst,
Michael D. Allen,
Jin Zhang

Published: May 21, 2009
https://doi.org/10.1371/journal.pone.0005642

About the Authors

Katie J. Herbst

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Michael D. Allen

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Jin Zhang

* E-mail: jzhang32@jhmi.edu

Affiliations Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The Solomon H. Snyder Department of Neuroscience and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJH MDA JZ. Performed the experiments: KJH. Analyzed the data: KJH MDA JZ. Contributed reagents/materials/analysis tools: MDA. Wrote the paper: KJH JZ.

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PKA signaling cascade
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Luciferase
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Bioluminescence
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Signal inhibition
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Luciferase assay
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Protein kinases
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Reporter gene assay
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Signal processing
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