Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

Christopher W. Wilson; Miao-Hsueh Chen; Pao-Tien Chuang

doi:10.1371/journal.pone.0005182

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Open Access

Peer-reviewed

Research Article

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

Christopher W. Wilson,

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
⨯
Miao-Hsueh Chen,

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
⨯
Pao-Tien Chuang

* E-mail: pao-tien.chuang@ucsf.edu

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
⨯

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

Christopher W. Wilson,
Miao-Hsueh Chen,
Pao-Tien Chuang

Published: April 13, 2009
https://doi.org/10.1371/journal.pone.0005182

About the Authors

Christopher W. Wilson

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Miao-Hsueh Chen

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Pao-Tien Chuang

* E-mail: pao-tien.chuang@ucsf.edu

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CW PTC. Performed the experiments: CW. Analyzed the data: CW PTC. Contributed reagents/materials/analysis tools: CW MHC. Wrote the paper: CW PTC.

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Cilia
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Hedgehog signaling
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Toxins
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DNA transcription
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Luciferase
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DAPI staining
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Transcription factors
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Protein transport
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