Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models

Takuya Tamura; Masaki Sone; Mayumi Yamashita; Erich E. Wanker; Hitoshi Okazawa

doi:10.1371/journal.pone.0004262

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Peer-reviewed

Research Article

Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models

Takuya Tamura,

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Masaki Sone,

Affiliation Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Mayumi Yamashita,

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Erich E. Wanker,

Affiliation Department of Neurogenetics, Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany
⨯
Hitoshi Okazawa

* E-mail: okazawa-tky@umin.ac.jp

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯

Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models

Takuya Tamura,
Masaki Sone,
Mayumi Yamashita,
Erich E. Wanker,
Hitoshi Okazawa

Published: January 23, 2009
https://doi.org/10.1371/journal.pone.0004262

About the Authors

Takuya Tamura

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Masaki Sone

Affiliation Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Mayumi Yamashita

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Erich E. Wanker

Affiliation Department of Neurogenetics, Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany

Hitoshi Okazawa

* E-mail: okazawa-tky@umin.ac.jp

Affiliation Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HO. Performed the experiments: TT MS MY. Analyzed the data: TT MS MY HO. Contributed reagents/materials/analysis tools: EEW HO. Wrote the paper: TT HO.

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Pupae
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Immunohistochemistry techniques
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Cell staining
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Cytopathology
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Neurons
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Drosophila melanogaster
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Larvae
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