Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

Nilgun Isik; Dale Hereld; Tian Jin

doi:10.1371/journal.pone.0003424

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Open Access

Peer-reviewed

Research Article

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

Nilgun Isik,

Affiliation Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, Rockville, Maryland, United States of America
⨯
Dale Hereld,

Current address: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America

Affiliation Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, Rockville, Maryland, United States of America
⨯
Tian Jin

* E-mail: tjin@niaid.nih.gov

Affiliation Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, Rockville, Maryland, United States of America
⨯

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

Nilgun Isik,
Dale Hereld,
Tian Jin

Published: October 16, 2008
https://doi.org/10.1371/journal.pone.0003424

About the Authors

Nilgun Isik

Affiliation Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, Rockville, Maryland, United States of America

Dale Hereld

Current address: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America

Tian Jin

* E-mail: tjin@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NI TJ. Performed the experiments: NI. Analyzed the data: NI TJ. Contributed reagents/materials/analysis tools: NI TJ. Wrote the paper: DH TJ.

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Fluorescence resonance energy transfer
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CCR5 coreceptor
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Chemokines
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Cell membranes
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Yellow fluorescent protein
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Fluorescence imaging
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Dimers
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T cell receptors
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