About the Authors

Xiao-Song He

Contributed equally to this work with: Xiao-Song He, Tyson H. Holmes

xiaosong@Stanford.edu

Affiliations Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, VA Palo Alto Health Care System, Palo Alto, California, United States of America

Tyson H. Holmes

Contributed equally to this work with: Xiao-Song He, Tyson H. Holmes

Affiliation Department of Health Research and Policy (Biostatistics), Stanford University School of Medicine, Stanford, California, United States of America

Sanae Sasaki

Affiliations Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, VA Palo Alto Health Care System, Palo Alto, California, United States of America

Maria C. Jaimes

Current address: BD Biosciences, San Jose, California, United States of America

Affiliations Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, VA Palo Alto Health Care System, Palo Alto, California, United States of America

George W. Kemble

Affiliation MedImmune Vaccines, Mountain View, California, United States of America

Cornelia L. Dekker

Affiliation Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

Ann M. Arvin

These authors also contributed equally to this work.

Affiliations Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

Harry B. Greenberg

These authors also contributed equally to this work.

Affiliations Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, VA Palo Alto Health Care System, Palo Alto, California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

Competing Interests

G. W. Kemble is an employee of MedImmune Vaccines, the manufacturer of LAIV used in this study.

Author Contributions

Conceived and designed the experiments: HG AA XH. Performed the experiments: XH SS MJ. Analyzed the data: TH. Contributed reagents/materials/analysis tools: GK. Wrote the paper: HG AA XH TH CD. Other: Directed the study: HG AA. Directed the clinical core: CD. Provided HAI data: GK. Designed the data analysis strategy: TH.