Gating at the Mouth of the Acetylcholine Receptor Channel: Energetic Consequences of Mutations in the αM2-Cap

Pallavi A. Bafna; Prasad G. Purohit; Anthony Auerbach

doi:10.1371/journal.pone.0002515

Loading metrics

Open Access

Peer-reviewed

Research Article

Gating at the Mouth of the Acetylcholine Receptor Channel: Energetic Consequences of Mutations in the αM2-Cap

Pallavi A. Bafna,

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America
⨯
Prasad G. Purohit,

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America
⨯
Anthony Auerbach

* E-mail: auerbach@buffalo.edu

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America
⨯

Gating at the Mouth of the Acetylcholine Receptor Channel: Energetic Consequences of Mutations in the αM2-Cap

Pallavi A. Bafna,
Prasad G. Purohit,
Anthony Auerbach

Published: June 25, 2008
https://doi.org/10.1371/journal.pone.0002515

About the Authors

Pallavi A. Bafna

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America

Prasad G. Purohit

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America

Anthony Auerbach

* E-mail: auerbach@buffalo.edu

Affiliation Department of Biophysics and Physiology, State University of New York at Buffalo, Buffalo, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AA PB. Performed the experiments: PB PP. Analyzed the data: PB. Contributed reagents/materials/analysis tools: AA. Wrote the paper: AA PB.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ion channel gating
Is the Subject Area "Ion channel gating" applicable to this article?

Thanks for your feedback.
Cholines
Is the Subject Area "Cholines" applicable to this article?

Thanks for your feedback.
Substitution mutation
Is the Subject Area "Substitution mutation" applicable to this article?

Thanks for your feedback.
Alpha helix
Is the Subject Area "Alpha helix" applicable to this article?

Thanks for your feedback.
Chemical dissociation
Is the Subject Area "Chemical dissociation" applicable to this article?

Thanks for your feedback.
Proline
Is the Subject Area "Proline" applicable to this article?

Thanks for your feedback.
Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
Free energy
Is the Subject Area "Free energy" applicable to this article?

Thanks for your feedback.