Cerebrospinal Fluid Viral Load and Intrathecal Immune Activation in Individuals Infected with Different HIV-1 Genetic Subtypes

Sahra Abdulle; Lars Hagberg; Bo Svennerholm; Dietmar Fuchs; Magnus Gisslén

doi:10.1371/journal.pone.0001971

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Open Access

Peer-reviewed

Research Article

Cerebrospinal Fluid Viral Load and Intrathecal Immune Activation in Individuals Infected with Different HIV-1 Genetic Subtypes

Sahra Abdulle ,

*To whom correspondence should be addressed. E-mail: sahra.abdulle@infect.gu.se

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
⨯
Lars Hagberg,

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
⨯
Bo Svennerholm,

Affiliation Department of Virology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
⨯
Dietmar Fuchs,

Affiliation Division of Biological Chemistry, Biocentre, Innsbruck Medical University & Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
⨯
Magnus Gisslén

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
⨯

Cerebrospinal Fluid Viral Load and Intrathecal Immune Activation in Individuals Infected with Different HIV-1 Genetic Subtypes

Sahra Abdulle,
Lars Hagberg,
Bo Svennerholm,
Dietmar Fuchs,
Magnus Gisslén

Published: April 16, 2008
https://doi.org/10.1371/journal.pone.0001971

About the Authors

Sahra Abdulle

*To whom correspondence should be addressed. E-mail: sahra.abdulle@infect.gu.se

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Lars Hagberg

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Bo Svennerholm

Affiliation Department of Virology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Dietmar Fuchs

Affiliation Division of Biological Chemistry, Biocentre, Innsbruck Medical University & Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria

Magnus Gisslén

Affiliation Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Contributed to the conception of the study, data interpretation, and the writing of the paper: MG LH SA. Performed the neopterin analysis and assisted in drafting the manuscript: DF. Conducted the subtyping and helped in drafting the manuscript: BS.

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Cerebrospinal fluid
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HIV-1
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Opportunistic infections
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Central nervous system
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Polymerase chain reaction
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Viral load
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Blood plasma
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RNA analysis
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