Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo

Jonghwan Kim; Ji-hoon Lee; Vishwanath R. Iyer

doi:10.1371/journal.pone.0001798

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Open Access

Peer-reviewed

Research Article

Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo

Jonghwan Kim,

Current address: Hematology and Oncology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America

Affiliation Section of Molecular Genetics and Microbiology, Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
⨯
Ji-hoon Lee,

Affiliation Section of Molecular Genetics and Microbiology, Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
⨯
Vishwanath R. Iyer

*To whom correspondence should be addressed. E-mail: vishy@mail.utexas.edu

Affiliation Section of Molecular Genetics and Microbiology, Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
⨯

Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo

Jonghwan Kim,
Ji-hoon Lee,
Vishwanath R. Iyer

Published: March 12, 2008
https://doi.org/10.1371/journal.pone.0001798

About the Authors

Jonghwan Kim

Current address: Hematology and Oncology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America

Affiliation Section of Molecular Genetics and Microbiology, Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

Ji-hoon Lee

Vishwanath R. Iyer

*To whom correspondence should be addressed. E-mail: vishy@mail.utexas.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VI JK. Performed the experiments: JK JL. Analyzed the data: JK. Wrote the paper: VI JK.

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Fibroblasts
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Mitochondria
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HeLa cells
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Biosynthesis
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Cell binding
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Gene expression
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Microarrays
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Transcription factors
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