Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

Anuradha Alahari; Xavier Trivelli; Yann Guérardel; Lynn G. Dover; Gurdyal S. Besra; James C. Sacchettini; Robert C. Reynolds; Geoffrey D. Coxon; Laurent Kremer

doi:10.1371/journal.pone.0001343

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Research Article

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

Anuradha Alahari,

Affiliation Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, Centre National de la Recherche Scientifique (CNRS), UMR 5235, Montpellier, France
⨯
Xavier Trivelli,

Affiliation Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France
⨯
Yann Guérardel,

Affiliation Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France
⨯
Lynn G. Dover,

Affiliation Biomolecular and Biomedical Research Centre, School of Applied Science, Northumbria University, Newcastle upon Tyne, United Kingdom
⨯
Gurdyal S. Besra,

Affiliation School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯
James C. Sacchettini,

Affiliation Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America
⨯
Robert C. Reynolds,

Affiliation Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, United States of America
⨯
Geoffrey D. Coxon,

Affiliation Division of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
⨯
Laurent Kremer

*To whom correspondence should be addressed. E-mail: laurent.kremer@univ-montp2.fr

Affiliations Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, Centre National de la Recherche Scientifique (CNRS), UMR 5235, Montpellier, France, INSERM, Dynamique des Interactions Membranaires Normales et Pathologiques (DIMNP), Montpellier, France
⨯

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

Anuradha Alahari,
Xavier Trivelli,
Yann Guérardel,
Lynn G. Dover,
Gurdyal S. Besra,
James C. Sacchettini,
Robert C. Reynolds,
Geoffrey D. Coxon,
Laurent Kremer

Published: December 19, 2007
https://doi.org/10.1371/journal.pone.0001343

About the Authors

Anuradha Alahari

Affiliation Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, Centre National de la Recherche Scientifique (CNRS), UMR 5235, Montpellier, France

Xavier Trivelli

Affiliation Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

Yann Guérardel

Affiliation Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

Lynn G. Dover

Affiliation Biomolecular and Biomedical Research Centre, School of Applied Science, Northumbria University, Newcastle upon Tyne, United Kingdom

Gurdyal S. Besra

Affiliation School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

James C. Sacchettini

Affiliation Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

Robert C. Reynolds

Affiliation Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, United States of America

Geoffrey D. Coxon

Affiliation Division of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

Laurent Kremer

*To whom correspondence should be addressed. E-mail: laurent.kremer@univ-montp2.fr

Affiliations Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, Centre National de la Recherche Scientifique (CNRS), UMR 5235, Montpellier, France, INSERM, Dynamique des Interactions Membranaires Normales et Pathologiques (DIMNP), Montpellier, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LK YG AA. Performed the experiments: LK YG AA XT lD GC. Analyzed the data: LK GB YG AA XT JS. Contributed reagents/materials/analysis tools: RR. Wrote the paper: LK AA.

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Mycobacterium tuberculosis
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Mycobacterium bovis
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Lipids
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Thin-layer chromatography
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Chemical synthesis
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Drug therapy
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Cell walls
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Bovine tuberculosis
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