About the Authors
- Marcella Funicello
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Michela Novelli
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Affiliation Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology, University of Pisa, Pisa, Italy
- Maurizio Ragni
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Teresa Vottari
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Cesare Cocuzza
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Joaquin Soriano-Lopez
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Chiara Chiellini
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Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Federico Boschi
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Affiliation Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, Medical Faculty, University of Verona, Verona, Italy
- Pasquina Marzola
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Affiliation Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, Medical Faculty, University of Verona, Verona, Italy
- Pellegrino Masiello
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Affiliation Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology, University of Pisa, Pisa, Italy
- Paul Saftig
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Affiliation Biochemical Institute, Christian-Albrechts University, Kiel, Germany
- Ferruccio Santini
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Affiliation Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Rene St-Jacques
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Affiliation Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
- Sylvie Desmarais
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Affiliation Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
- Nicolas Morin
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Affiliation Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
- Joseph Mancini
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Affiliation Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
- M. David Percival
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Affiliation Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
- Aldo Pinchera
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Affiliation Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
- Margherita Maffei
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*To whom correspondence should be addressed. E-mail: mmaffei@dti.telethon.it
Affiliation Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
Competing Interests
Rene St-Jacques, Sylvie Desmarais, Nicolas Morin, Joseph Mancini and M. David Percival are employees of Merck and Co., Inc. which is investigating Cathepsin K inhibitors as potential therapeutics. All the other authors do not disclose any competing interest.
Author Contributions
Conceived and designed the experiments: MM. Performed the experiments: MF MN MR TV CC JS CC FB RS SD NM JM. Analyzed the data: MF MN MR TV JS CC PM PM RS SD NM JM. Contributed reagents/materials/analysis tools: PS AP FS. Wrote the paper: MM PM FS MP.